Véronique Gouverneur Research

Department of Chemistry University of Oxford



216 [18F]Difluorocarbene for Positron Emission Tomography
J. B. I. Sap,  C. F. Meyer, J. Ford, N. J. W. Straathof, A. B. Dürr, M. J. Lelos, S. J. Paisey, T. A. Mollner, S. M. Hell, A. A. Trabanco, C. Genicot,  C. W. am Ende, R. S. Paton, M. Tredwell, V. Gouverneur
Nature 2022. DOI:10.1038/s41586-022-04669-2

215 Multi-patient dose synthesis of [18F]Flumazenil via a copper-mediated 18 F-fluorination
T. Gendron,  G. Destro, N. J. W. Straathof, J. B. I. Sap, F. Guibbal, C. Vriamont, C. Caygill, J. R. Atack, A. J. Watkins, C. Marshall, R. Hueting, C. Warnier,  V. Gouverneur, M. Tredwell
EJNMMI radiopharm. chem. 2022, 7, 5. DOI:10.1186/s41181-022-00158-z


214 Hydrogen Bonding Phase-Transfer Catalysis with Alkali Metal Fluorides and Beyond
G. Pupo, V. Gouverneur
J. Am. Chem. Soc. 2022, 144, 5200-5213. DOI:10.1021/jacs.2c00190


213 Asymmetric Azidation under Hydrogen Bonding Phase-Transfer Catalysis: A Combined Experimental and Computational Study
J. Wang, M. A. Horwitz, A. B. Dürr, F. Ibba, G. Pupo, Y. Gao, P. Ricci, K. E. Christensen, T. P. Pathak, T. D. W. Claridge, G. C. Lloyd-Jones, R. S. Paton, V. Gouverneur
J. Am. Chem. Soc. 2022, 144, 4572-4584. DOI:10.1021/jacs.1c13434

212 Scalable Synthesis of (R,R)-N,N-Dibenzyl-2-fluorocyclohexan-1-amine with CsF under Hydrogen Bonding Phase-Transfer Catalysis
A. C. Vicini, D-M Alozie, P. Courtes, G. Roagna, C. Aubert, V. Certal, Y. El-Ahmad, S. Roy, V. Gouverneur
Org. Process Res. Dev. 2021, 25, 2730–2737. DOI:10.1021/acs.oprd.1c00312

211 Multigram synthesis of N-alkyl bis-ureas for asymmetric hydrogen bonding phase-transfer catalysis
A. C. Vicini, G. Pupo, F. Ibba, V. Gouverneur
Nat. Protoc. 2021, 16, 5559–5591. DOI:10.1038/s41596-021-00625-y

Highlighted on: Protocols & Methods Community

210 Post-translational insertion of boron in proteins to probe and modulate function
T. A. Mollner, P. G. Isenegger, B. Josephson, C. Buchanan, L. Lercher, D. Oehlrich, D. Flemming Hansen, S. Mohammed, A. J. Baldwin, V. Gouverneur, B. G. Davis 
Nat. Chem. Biol. 2021, 17, 1245–1261. DOI:10.1038/s41589-021-00883-7 


209 Closing the gap between 19F and 18F chemistry
J. Ajenjo, G. Destro, F. Guibbal, B. Cornelissen, V. Gouverneur 
EJNMMI radiopharm. chem. 2021, 6, 33. DOI:10.1186/s41181-021-00143-y


208 Copper-Mediated Radiosynthesis of [18F]Rucaparib
Z. Chen, G. Destro, F. Guibbal, C. Y. Chan, B. Cornelissen, V. Gouverneur 
Org. Lett. 202123, 7290–7294. DOI:10.1021/acs.orglett.1c02770


207 Hydrofluoromethylation of alkenes with fluoroiodomethane and beyond
S. M. Hell, C. F. Meyer, S. Ortalli, J. Sap, X. Chen, V. Gouverneur 
Chem. Sci. 2021, 12, 12149-12155. DOI:10.1039/d1sc03421a


206 Contemporary synthetic strategies in organofluorine chemistry
R. Britton, V. Gouverneur, J.-H Lin, M. Meanwell, C. Ni, G. Pupo, J.-C. Xiao, J. Hu 
Nat. Rev. Methods Primers. 2021, 1, 47. DOI:10.1038/s43586-021-00042-1


205 Late-stage difluoromethylation: concepts, developments and perspective
J. B. I. Sap, C. F. Meyer, N. J. W. Straathof, N. Iwumene, C. W. am Ende, A. A. Trabanco, V. Gouverneur 
Chem. Soc. Rev. 2021, 50, 8214 - 8247. DOI:10.1039/D1CS00360G


204 Residue-Selective Protein C-Formylation via Sequential Difluoroalkylation-Hydrolysis
M. Imiołek, P. G. Isenegger, W. Ng, A. Khan, V. Gouverneur, B. G. Davis
ACS Cent. Sci. 2021, 7, 145-155. DOI:10.1021/acscentsci.0c01193


203 18F-meta-fluorobenzylguanidine (18F-mFBG) to monitor changes in norepinephrine transporter expression in response to therapeutic intervention in neuroblastoma models
S. Turnock, D. R. Turton, C. D. Martins, L. Chesler, T. C. Wilson, V. Gouverneur, G. Smith, G. Kramer-Marek
Sci. Rep. 2020, 10, 1-12. DOI:10.1038/s41598-020-77788-3


202 Impact of Multiple Hydrogen Bonds with Fluoride on Catalysis: Insight from NMR Spectroscopy
F. Ibba, G. Pupo, A. L. Thompson, J. M. Brown, T. D. W. Claridge, V. Gouverneur
J. Am. Chem. Soc. 2020, 142, 19731–19744. DOI:10.1021/jacs.0c09832


201 Light-driven post-translational installation of reactive protein side chains
B. Josephson, C. Fehl, P. G. Isenegger, S. Nadal, T. H. Wright, A. W. J. Poh, B. J. Bower, A. M. Giltrap, L. Chen, C. Batchelor-McAuley, G. Roper, O. Arisa, J. B. I. Sap, A. Kawamura, A. J. Baldwin, S. Mohammed, R. G. Compton, V. Gouverneur, B. G. Davis
Nature 2020, 585, 530–537. DOI:10.1038/s41586-020-2733-7

Highlighted in: Radical post-translational modifications
X. Jiang
Chemistry World. 2021


200 Radiosynthesis of [18F]ArylSCF2H using aryl boronic acids, S-(chlorofluoromethyl)benzenesulfonothioate and [18F]fluoride
Q. Zhao, P. G. Isenegger, T. C. Wilson, J. B. I. Sap, F. Guibbal, L. Lu, V. Gouverneur, Q. Shen
Chinese Chem. Soc. Chem. 2020, 2, 1921–1928. DOI:10.31635/ccschem.020.202000399


199 Synthesis of Fluorinated Alkyl Aryl Ethers by Palladium-Catalyzed C-O Cross-Coupling
R. Szpera, P. G. Isenegger, M. Ghosez, N. J. W. Straathof, R. Cookson, D. C. Blakemore, P. Richardson, V. Gouverneur
Org. Lett. 2020, 22, 6573–6577. DOI:10.1021/acs.orglett.0c02347


198 Hydrogen Bonding Phase-Transfer Catalysis with Ionic Reactants: Enantioselective Synthesis of γ-Fluoroamines
G. Roagna, D. Ascough, F. Ibba, A. C. Vicini, A. Fontana, K. Christensen, A. Peschiulli, D. Oehlrich, M. Misale, A. Trabanco, R. Paton, G. Pupo, V. Gouverneur
J. Am. Chem. Soc. 2020, 142, 14045–14051. DOI:10.1021/jacs.0c05131

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Highlighted in: Bisurea-Catalyzed Enantioselective Synthesis of γ-Fluoroamines
B. List, Y.Li
Synfacts 2020, 16, 1099–1100. DOI:10.1055/s-0040-1706771


197 Organophotoredox Hydrodefluorination of Trifluoromethylarenes with Translational Applicability to Drug Discovery

J. B. I. Sap, N. J. W. Straathof, T. Knauber, C. F. Meyer, M. Médebielle, L. Buglioni, C. Genicot, A. A. Trabanco, T. Noël, C. W. am Ende, V. Gouverneur
J. Am. Chem. Soc. 2020, 142, 9181–9187. DOI:10.1021/jacs.0c03881

Highlighted in: Some Items of Interest to Process R&D Chemists and Engineers
W. Zhao, S. Guizzetti, J. A. Schwindeman, D. S. B. Daniels, J. J. Douglas, S. Petit, C. B. Kelly, A. Kosanovich, J. Knight
Org. Process Res. Dev. 2020, 24, 1351-1363. DOI:10.1021/acs.oprd.0c00344


196 [18F]AZD2461, an Insight on Difference in PARP Binding Profiles for DNA Damage Response PET Imaging
F. Guibbal, S. L. Hopkins, A. Pacelli, P. G. Isenegger, M. Mosley, J. B. Torres, G. M. Dias,    D. Mahaut, R. Hueting, V. Gouverneur, B. Cornelissen
Mol Imaging Biol. 2020, 22, 12261234. DOI:10.1007/s11307-020-01497-6


195 Hydrosulfonylation of Alkenes with Sulfonyl Chlorides under Visible Light Activation
S. M. Hell, C. F. Meyer, A. Misale, J. B. Sap, K. E. Christensen, M. C. Willis, A. A. Trabanco, V. Gouverneur
Angew. Chem. Int. Ed. 2020, 59, 11620–11626. DOI:10.1002/anie.202004070


194 Manual and automated Cu-mediated radiosynthesis of the PARP inhibitor

F. Guibbal, P. G. Isenegger, T. C. Wilson, A. Pacelli, D. Mahaut, J. B. I. Sap, N. J. Taylor, S. Verhoog, S. Preshlock, R. Hueting, B. Cornelissen, V. Gouverneur

Nat Protoc. 2020, 15, 15251541. DOI:10.1038/s41596-020-0295-7


193 18F-Trifluoromethanesulfinate enables Direct C–H 18F-Trifluoromethylation of Native Aromatic Residues in Peptides
C. W. Kee, O. Tack, F. Guibbal, T. C. Wilson, P. G. Isenegger, M. Imiołek, S Verhoog, M. Tilby, G. Boscutti, S. Ashworth, J Chupin, R. Kashani, A. W. J. Poh, J. K. Sosabowski, S. Macholl, C. Plisson, B. Cornelissen, M. C. Willis, J. Passchier, B. G. Davis, V. Gouverneur
J. Am. Chem. Soc. 2020, 142, 1180-1185. DOI:10.1021/jacs.9b11709


192 Silyl Radical-Mediated Activation of Sulfamoyl Chlorides Enables Direct Access to Aliphatic Sulfonamides from Alkenes
S. M. Hell, C. F. Meyer, G. Laudadio, A. Misale, M. C. Willis, T. Noel, A. A. Trabanco, V. Gouverneur
J. Am. Chem. Soc. 2020, 142, 720-725. DOI:10.1021/jacs.9b13071

Highlighted in: Easy Access to Aliphatic Sulfonamides using Sulfamoyl Chlorides Under Visible Light Activation
S. M. Hell, C. F. Meyer, A. A. Trabanco, V. Gouverneur 
J. Vis. Exp. 2020. DOI:10.3791/61384

Highlighted on the Organic Chemistry Portal


191 Hydrochlorofluoromethylation of Unactivated Alkenes with Chlorofluoroacetic Acid
C. F. Meyer, S. M. Hell, J. B. I. Sap, A. Misale, A. Peschiulli, D. Oehlrich, A. A. Trabanco, V. Gouverneur
Invited contribution to the special issue in honour of Professor Steve Davies.
Tetrahedron 2019, 75, 130679-130680. DOI:10.1016/j.tet.2019.130679


190 Imaging of translocator protein upregulation is selective for pro-inflammatory polarised astrocytes and microglia
M. Pannell, V. Economopoulos, T. C. Wilson, V.  Kersemans, P. G. Isenegger, J. R. Larkin, S. Smart, S. Gilchrist, V. Gouverneur, N. R. Sibson
GLIA 2019, 68, 280-297. DOI:10.1002/glia.23716


 189 In My Element: Fluorine
V. Gouverneur
In My Element series celebrates the personal accounts from Chemistry-
A European Journal Editorial Board members for the 2019 International Year
of the Periodic Table.
Chem. Eur. J.  2019, 25, 7958- 7959. DOI:10.1002/chem.201902265


 188 Hydrodifluoromethylation of Alkenes with Difluoroacetic Acid
C. F. Meyer, S. M. Hell, A. Misale, A. A. Trabanco, V. Gouverneur
Angew. Chem. Int. Ed. 2019, 58, 8828- 8833. DOI:10.1002/anie.201903801


187 The fluorination of C–H bonds: developments and perspectives
R. Szpera, D. F. J. Moseley, L. B. Smith, A. J. Sterling, V. Gouverneur
Angew. Chem. Int. Ed. 2019, 58, 14824-14848. DOI:10.1002/anie.201814457


186 Synthesis of 18F-Difluoromethylarenes Using Aryl Boronic Acids, Ethyl bromofluoroacetate and [18F]Fluoride
J. B. I. Sap, T. C. Wilson, C. W. Kee, N. J. W. Straathof, C. W. Amende, P. Mukherjee, L. Zhang, C. Genicot, V. Gouverneur
Chem. Sci. 2019, 10, 3237 - 3241. DOI: 10.1039/C8SC05096A


185 Hydrogen Bonding Phase-Transfer Catalysis with Potassium Fluoride: Enantioselective Synthesis of β-Fluoroamines
G. Pupo, A. C. Vicini, D. M. H. Ascough, F. Ibba, K. E. Christensen, A. L. Thompson, J. M. Brown, R. S. Paton, V. Gouverneur
J. Am. Chem. Soc. 2019, 141, 2878–2883. DOI: 10.1021/jacs.8b12568


184 Synthesis and Reactivity of a-Cumyl Bromodifluoromethanesulfenate: Application to the Radiosynthesis of [18F]ArylSCF3
J. Wu, Q. Zhao, T. C. Wilson, S. Verhoog, L. Lu, V. Gouverneur and Q. Shen
Angew. Chem. Int. Ed. 2019, 58, 1-6. DOI: 10.1002/anie.20181370


183 Data-mining the diaryl(thio)urea conformational landscape: Understanding the contrasting behavior of ureas and thioureas with quantum chemistry
G. Luchini, D. M. H. Ascough, J. V. Alegre-Requena, V. Gouverneur, R. S. Paton
Special Issue Paper: Computational Chemistry in Organic Synthesis. Guest Editors: Dean Tantillo and John Wood
Tetrahedron 2019, 75, 697-702. DOI: 10.1016/j.tet.2018.12.033


182 Enantioselective rhodium-catalysed insertion of trifluorodiazoethanes into tin hydrides S. Hyde, J. Veliks, D. M. H. Ascough, R. Szpera, R. S. Paton, V. Gouverneur
Special Issue in honour of Prof Leon Ghosez
Tetrahedron 2019, 75, 17-25. DOI: 10.1016/j.tet.2018.11.022


181 PET Imaging of PARP Expression Using 18F-Olaparib
T. C. Wilson, M. A. Xavier, J. Knight, S. Verhoog, J. B. Torres, M. Mosley, S. L. Hopkins, S. Wallington, P. D. Allen, V. Kersemans, R. Hueting, S. Smart, V. Gouverneur, B. Cornelissen
J. Nucl. Med. 2018, 60, 504-510. DOI: 10.2967/jnumed.118.213223


180 Boron reagents for divergent radiochemistry
T. C. Wilson, T. Cailly, V. Gouverneur
Chem Soc Rev2018, 47, 6990-7005. DOI: 10.1039/c8cs00499d



179 Asymmetric nucleophilic fluorination under hydrogen bonding phase-transfer catalysis
G. Pupo, F. Ibba, D. M. H. Ascough, A. C. Vicini, P. Ricci, K. E. Christensen, L. Pfeifer, J. R. Morphy, J. M. Brown, R. S. Paton, V. Gouverneur
Science 2018, 360, 638-642. DOI: 10.1126/science.aar7941


 178 Highly Diastereoselective Synthesis of Trifluoromethyl Indolines by Interceptive Benzylic Decarboxylative Cycloaddition of Nonvinyl, Trifluoromethyl Benzoxazinanones with Sulfur Ylides under Palladium Catalysis
N. Punna, P. Das, V. Gouverneur, N. Shibata

Org. Lett. 2018, 20, 1526-1529. DOI: 10.1021/acs.orglett.8b00237


177 Controlled Single and Double Iodofluorination of Alkynes with DIH- and HF-Based Reagents
L. Pfeifer, V. Gouverneur

Org. Lett. 2018, 20, 1576-1579. DOI: 10.1021/acs.orglett.8b00321


176 Selective Radical Trifluoromethylation of Native Residues in Proteins
M. Imiołek, G. Karunanithy, W-L. Ng, A. J. Baldwin, V. Gouverneur, B. G. Davis
J. Am. Chem. Soc. 2018, 7, 1568-1571. DOI: 10.1021/jacs.7b10230



175 18F-Trifluoromethylation of Unmodified Peptides with 5-18F-(Trifluoromethyl)dibenzothiophenium Trifluoromethanesulfonate
S. Verhoog, C. W. Kee, Y. Wang, T. Khotavivattana, T. C. Wilson, V. Kersemans, S. Smart, M. Tredwell, B. G. Davis, V. Gouverneur
J. Am. Chem. Soc. 2018, 7, 1572-1575. DOI: 10.1021/jacs.7b10227


174 Synthesis, characterization, thermal and surface properties of co- and terpolymers based on fluorinated a-methylstyrenes and styrene
J. Walkowiak-Kulikowska, A. Szwajca, V. Gouverneur, B. Ameduri 
Polym. Chem-Uk 2017, 8, 6558-6569. DOI: 10.1039/C7PY01529A


173 De-Risking the Cu-Mediated 18F-Fluorination of Heterocyclic PET Radioligands
N. J. Taylor, E. Emer, S. Preshlock, M. Schedler, M. Tredwell, S. Verhoog, J. Mercier, C. Genicot, V. Gouverneur
J. Am. Chem. Soc. 2017, 139, 8267-8276. DOI: 10.1021/jacs.7b03131


172 Synthesis and Reactivity of 18F-Labeled α,α-Difluoro-α-Aryloxyacetic Acids
T. Khotavivattana, S. Calderwood, S. Verhoog, L. Pfeifer, S. Preshlock, N. Vasdev, T. L. Collier, V. Gouverneur
Org. Lett. 2017, 19, 568-571. DOI: 10.1021/acs.orglett.6b03730


171 The Dual Role of Thiourea in the Thiotrifluoromethylation of Alkenes 
P. Ricci, T. Khotavivattana, L. Pfeifer, M. Médebielle, J. R. Morphy, V. Gouverneur 
Chem. Sci. 2017, 8, 1195-1199. DOI: 10.1039/C6SC02790C


170 Bridging the gaps in 18F PET tracer development 
M. G. Campbell, J. Mercier, C. Genicot, V. Gouverneur, J. M. Hooker, T. Ritter 
Nat. Chem.
2017, 9, 1-3. DOI: 10.1038/nchem.2693 



169 Twisting the Ethano-Tröger’s Base: The Bisamide 
R. Pereira, L. Pfeifer, J. Fournier, V. Gouverneur V, J. Cvengroš
Org. Biomol. Chem. 2017, 15, 628-633. DOI: 10.1039/C6OB02359B