Véronique Gouverneur Research

Department of Chemistry University of Oxford


168 Radiosynthesis of SPECT tracers via a copper mediated 123I iodination of (hetero)aryl boron reagents 
T. C. Wilson, G. McSweeney, S. Preshlock, S. Verhoog, M. Tredwell, T. Cailly, V. Gouverneur 
Chem. Commun. 2016, 52, 13277-13280.

167 On the Reactivity of α-Trifluoromethylstyrene in Radical Copolymerizations with Various Fluoroalkenes 
J. Walkowiak-Kulikowska, F. Boschet, G. Kostov, V. Gouverneur, B. Ameduri 
Eur. Polym. J. 2016, 84, 612-621.

166 Targeting telomerase with radiolabeled inhibitors 
P. A. Waghorna, M. R. Jackson, V. Gouverneur, K. A. Vallis 
Eur. J. Med. Chem. 2017, 125, 117-129.

165 Hydrogen-Bonded Homoleptic Fluoride–Diarylurea Complexes: Structure, Reactivity and Coordinating Power 
L. Pfeifer, K. M. Engle, G. W. Pidgeon, H. A. Sparkes, A. L. Thompson, J. M. Brown, V. E. Gouverneur 
J. Am. Chem. Soc., 2016, 138 (40), 13314-13325.

164 Ultrafast Click Chemistry with Fluorosydnones
H. Liu, D. Audisio, L. Plougastel, E. Decuypere, D. A. Buisson, O. Koniev, S. Kolodych, A. Wagner, M. Elhabiri, A. Krzyczmonik, S. Forsback, O. Solin, V. Gouverneur, F. Taran 
Angew. Chem. Int. Ed. 2016, 55 (39), 12073-12077.

163 Enhanced Copper-Mediated 18F-Fluorination of Aryl Boronic Esters provides Eight Radiotracers for PET Applications
S. Preshlock, S. Calderwood, S. Verhoog, M. Tredwell, M. Huiban, A. Hienzsch, S. Gruber, T. C. Wilson, N. J. Taylor, T. Cailly, M. Schedler, T. L. Collier, J. Passchier, R. Smits, J. Mollitor, A. Hoepping, M. Mueller, C. Genicot, J. Mercier, V. Gouverneur
Chem. Commun. 2016, 52, 8361-8364.

162 Asymmetric 18F-Fluorination for Applications in Positron Emission Tomography
F. Buckingham, V. Gouverneur
Chem. Sci. 2016, 7, 1645-1652.

161 18F-Labeling of Arenes and Heteroarenes for Applications in Positron Emission Tomography
S. Preshlock, M. Tredwell, V. Gouverneur
Chem. Rev. 2016, 116 (2), 719–766.

160 Cu-Catalyzed Heteroatom-H Bond Insertions with Trifluorodiazoalkanes
S. Hyde, J. Veliks, B. Liégault, D. Grassi, M. Taillefer, V. Gouverneur
Angew. Chem. Int. Ed. 2016, 55 (11), 3785-3789.

159 Synthesis and Characterization of a Novel N-F Reagent derived from the Ethano-Tröger’s Base: 1JFN Coupling Constant as Signature for the N-F Bond
R. Pereira, J. Wolstenhulme, G. Sandford, T. D. W. Claridge, V. Gouverneur, J. Cvengroš
Chem. Commun. 2016, 52, 1606-1609.

158 Ag-Mediated 18F-Labeling of Aryl-CF3 and Aryl-CHF2 with 18F-Fluoride
S. Verhoog, L. Pfeifer, T. Khotavivattana, S. Calderwood, T. L. Collier, K. Wheelhouse, M. Tredwell, V. Gouverneur
Synlett 2016, 27, 25-28. In celebration of Prof. Steven Ley's 70th birthday.

157 Synthesis of 18F-Arenes from Spirocyclic Iodonium(III) Ylides via Continuous-Flow Microfluidics
S. Calderwood, T. L. Collier, V. Gouverneur, S. H. Liang, N. Vasdev
J. Fluorine Chem. 2015, 178, 249-253.

156 Organomediated Enantioselective 18F-Fluorination for PET Applications
F. Buckingham, A. K. Kirjavainen, S. Forsback, A. Krzyczmonik, T. Keller, I. M. Newington, M. Glaser, S. K. Luthra, O. Solin, V. Gouverneur
Angew. Chem. Int. Ed. 2015, 54 (45), 13366-13369.

155 Oxidative Fluorination of N-Arylsulfonamides 
F. Buckingham, S. Calderwood, B. Checa, T. Keller, M. Tredwell, T. L. Collier, I. M. Newington, R. Bhalla, M. Glaser, V. Gouverneur
J. Fluorine Chem. 2015, 180, 33-39.

154 Cross-Coupling of [2-Aryl-1,1,2,2-tetrafluoroethyl]trimethylsilanes with Aryl Halides 
M. O'Duill, E. Dubost, L. Pfeifer, V. Gouverneur
Organic Letters 2015, 17 (14), 3466-3469.

153 Coordination Diversity in Hydrogen-Bonded Homoleptic Fluoride–Alcohol Complexes Modulates Reactivity 
K. M. Engle, L. Pfeifer, G. W. Pidgeon, G. T. Giuffredi, A. L. Thompson, R. S. Paton, J. M. Brown, V. Gouverneur
Chem. Sci. 2015, 6, 5293-5302 (Edge Article).

152 [18F]Labeling of Aryl-SCF3, -OCF3 and -OCHF2 with [18F]Fluoride 
T. Khotavivattana, S. Verhoog, M. Tredwell, L. Pfeifer, S. Calderwood, K. Wheelhouse, T. L. Collier, V. Gouverneur
Angew. Chem. Int. Ed. 2015, 54 (34), 9991-9995.

151 Recruitment and Immobilization of a Fluorinated Biomarker Across an Interfacial Phospholipid Film using a Fluorocarbon Gas 
G. Yang, M. O'Duill, V. Gouverneur, M. P. Krafft
Angew. Chem. Int. Ed. 2015, 54 (29), 8402-8406.

150 A dual radiolabelling approach for tracking metal complexes: investigating the speciation of copper bis(thiosemicarbazonates) in vitro and in vivo 
R. Hueting, V. Kersemans, M. Tredwell, B. Cornelissen, M. Christlieb, A. D. Gee, J. Passchier, S. C. Smart, V. Gouverneur, R. J. Muschel, J. R. Dilworth
Metallomics 2015, 7, 795-804.

149 Iodine Transfer Copolymerization of Fluorinated α-Methylstyrenes with Styrene using 1-iodoperfluorohexane as the Chain Transfer Agent 
J. Walkowiak, A. Szwajca, F. Boschet, V. Gouverneur, B. Ameduri
Macromolecules 2014, 47(24), 8634–8644.

148 A Diversity Oriented Approach to CF3CHF-, CF3CFBr-, CF3CF2-, (CF3)2CH- and CF3(SCF3)CH-Substituted Arenes from 1-(Diazo-2,2,2-trifluoroethyl)arenes 
E. Emer, J. Twilton, M. Tredwell, S. Calderwood, T. Collier, B. Liégault, M. Taillefer, V. Gouverneur 
Org. Lett. 2014, 16(22), 6004-6007.

147 Asymmetric Fluorocyclizations of Alkenes 
J. Wolstenhulme, V. Gouverneur 
Account of Chemical Research 2014, 47(12), 3560-3570.

146 Anti-CD20 inhibits T cell-mediated pathology and microgliosis in the rat brain 
D. C. Anthony, A. M. Dickens, N. Seneca, Y. Couch, S. Campbell, B. Checa, V. Kersemans, E. A. Warren, M. Tredwell, N. R. Sibson, V. Gouverneur, D. Leppert 
Annals of Clinical and Translational Neurology 2014, 1 (9), 659–669.

145 A General Copper-Mediated Nucleophilic 18F Fluorination of Arenes 
M. Tredwell, S. M. Preshlock, N. J. Taylor, S. Gruber, M. Huiban, J. Passchier, J. Mercier, C. Génicot, V. Gouverneur 
Angew. Chem. Int. Ed. 2014, 53 (30), 7751-7755.

144 cis-Specific Hydrofluorination of Alkenylarenes under Palladium Catalysis by an Ionic Pathway 
E. Emer, L. Pfeifer, J. M. Brown, V. Gouverneur 
Angew. Chem. Int. Ed. 2014, 53 (16), 4181–4185.

143 Glial Activation in the Early Stages of Brain Metastasis: TSPO as a Diagnostic Biomarker 
E. R. O’Brien, V. Kersemans, M. Tredwell, B. Checa , S. Serres, M. S. Soto, V. Gouverneur, D. Leppert, D. C. Anthony, N. R. Sibson 
J. Nucl. Med. 2014, 55 (2), 1-6.

142 A Comparison of the Behaviour of 64Cu-acetate and 64Cu-ATSM in vitro and in vivo 
R. Hueting, V. Kersemans, B. Cornelissen, M. Tredwell, K. Hussien, M. Christlieb, A. D. Gee, J. Passchier, S. C Smart, J. R Dilworth, V. Gouverneur, R. J. Muschel 
J. Nucl. Med. 2014, 55 (1), 128-134

141 A Broadly Applicable [18F]Trifluoromethylation of Aryl and Heteroaryl Iodides for PET Imaging 
M. Huiban, M. Tredwell, S. Mizuta, Z. Wan, X. Zhang, T. L. Collier, V. Gouverneur, J. Passchier 
Nature Chemistry 2013, 5, 941-944

140 Enhanced Aqueous Suzuki-Miyaura Coupling Allows Site specific Polypeptide [18F]labeling 
M. Gao, V. Gouverneur, B. Davis 
J. Am. Chem. Soc., 2013, 135 (37), 13612–13615

139 Intramolecular OH...FC Hydrogen Bonding in Fluorinated Carbohydrates: CHF is a Better Hydrogen Bond Acceptor than CF2 
G. T. Giuffredi, V. Gouverneur, B. Bernet 
Angew. Chem. Int. Ed. 2013, 52 (40), 10524-10528

138 Asymmetric Electrophilic Fluorocarbocyclization with Carbon Nucleophiles 
J. R. Woltenshulme, J. Rosenqvist, O. Lozano, J. Ilupeju, K. M. Engle, G. Pidgeon, P. R. Moore, G. Sandford, V. Gouverneur 
Angew. Chem. Int. Ed. 2013, 52 (37), 9796–9800

137 Redox chemistry of trifluoromethyl sulfonium salts as CF3 radical sources 
S. Mizuta, S. Verhoog, X. Wang, N. Shibata, V. Gouverneur, M. Médebielle 
J. Fluorine Chem. 2013, 155, 124-131 (Special Issue in honor of Professor Ojima ACS Fluorine Award)

136 Catalytic Decarboxylative Fluorination for the Synthesis of Tri- and Difluoromethyl Arenes 
S. Mizuta, I. Stenhagen, M. O'Duill, J. Wolstenhulme, A. Kirjavainen, S. Forsback, M. Tredwell, G. Sandford, P. Moore, M. Huiban, S. Luthra, J. Passchier, O. Solin, V. Gouverneur 
Org. Lett. 2013, 15 (11), 2648-2651

135 Trifluoromethylation of Allylsilanes under Photoredox Catalysis 
S. Mizuta, K. M. Engle, S. Verhoog, O. Galicia-Lopez, M. O’Duill, M. Medebielle, K. Wheelhouse, G. Rassias, A. Thompson, V. Gouverneur 
Org. Lett. 2013, 15 (6), 1250-1253

134 Catalytic Hydrotrifluoromethylation of Unactivated Alkenes 
S. Mizuta, S. Verhoog, K. M. Engle, T. Khotavivattana M. O’Duill, K. Wheelhouse, G. Rassias, M. Medebielle, V. Gouverneur 
J. Am. Chem. Soc. 2013, 135 (7), 2505-2508

133 [18F]Fluorination of Arylboronic Ester using [18F]Selectfluor bis(triflate): Application to 6-[18F]Fluoro-L-DOPA 
I. S. R. Stenhagen, A. K. Kirjavainen, S. J. Forsback, C. G. Jørgensen, E. G. Robins, S. K. Luthra, O. Solin, V. Gouverneur 
Chem. Commun. 2013, 49, 1386-1388

132 Regio- and Stereoretentive Synthesis of Branched, Linear (E)- and (Z)-Allyl Fluorides from Allyl Carbonates under Ir-Catalysis
E. Benedetto, M. Tredwell, C. Hollingworth, T. Khotavivattana, J. M. Brown and V. Gouverneur 
Chem. Sci., 2013, 4, 89-96 [Back Cover]

131 [18F]Labeling of Arenes
M. Tredwell, V. Gouverneur
Angew. Chem. Int. Ed., 2012, 51 (46), 11426-11437.

130 Synthesis of 3-Fluoropyrrolidines and 4-Fluoropyrrolidin-2-ones from Allylic Fluorides
L. E. Combettes, M. Schuler, R. Patel, B. Bonillo, B. Odell, A. L. Thompson, T. D. W. Claridge, V. Gouverneur
Chemistry A European Journal, 2012, 18 (41), 13126-13132.

129 Conformational Analysis of Fluorinated Pyrrolidines using 19F-1H Scalar Couplings and Heteronuclear nOes
L. E. Combettes, P. Clausen-Thue, M. King, B. Odell, A. L. Thompson, V. Gouverneur, T. D. W. Claridge
Chemistry A European Journal, 2012, 18(41), 13133-13141.

128 Trifluoromethylation of Allylsilanes under Copper Catalysis
Satoshi Mizuta, Oscar Galicia-López, Keary M. Engle, Stefan Verhoog, Katherine Wheelhouse, Gerasimos Rassias, Véronique Gouverneur
Chemistry A European Journal, 2012, 18 (28), 8583-8587.

127 Metal-Free Oxidative Fluorination of Phenols with [18F]Fluoride 
Zhanghua Gao, Yee Hwee Lim, Matthew Tredwell, Lei Li, Stefan Verhoog, Matthew Hopkinson, Wojciech Kaluza, Thomas Lee Collier, Jan Passchier, Mickael Huiban, and Veronique Gouverneur
Angew. Chem. Int. Ed. 2012, 51 (27), 6733-6737.

126 Metal Free Fluoroamination of Allylsilanes: a Route to 3-Fluoropyrrolidines
Lorraine E. Combettes, Oscar Lozano and Véronique Gouverneur
J. Fluorine Chem., 2012, 143, 167-176 (Special issue of the Journal of Fluorine Chemistry to honor Professor David O'Hagan).

125 Palladium-Catalyzed Substitution and Cross-Coupling of Benzylic Fluorides 
George Blessley, Patrick Holden, Matthew Walker, John M. Brown and Véronique Gouverneur 
Org. Lett., 2012, 14 (11), 2754-2757.

124 Radiochemistry: Flipping fluoride's reactivity
Véronique Gouverneur 
Nature Chemistry, 2012, 4, 152-154.

123 A fluorous and click approach for screening potential PET probes: evaluation of potential hypoxia biomarkers
Romain Bejot, Laurence Carroll, Kishore Bhakoo and Véronique Gouverneur 
Bioorganic & Medicinal Chemistry 2012, 20, 324-329.

122 Platinum-Catalyzed Substitution of Allylic Fluorides
Elena Benedetto, Massaba Keita, Matthew Tredwell, Charlotte Hollingworth, John M. Brown and Véronique Gouverneur
Organometallics, 2012, 31 (4), 1408-1416.

121 Transition Metal Catalysis and Nucleophilic Fluorination
Charlotte Hollingworth and Véronique Gouverneur
Chem. Commun. 2012, 48, 2929-2942.

120 Supported Synthesis of Halogenated Organic Compounds
Sophie Boldon, Ida S. R. Stenhagen, Jane E. Moore, Sajinder K. Luthra, Véronique Gouverneur 
Synthesis 2011, 24, 3929-3953.

119 Organocatalyzed Enantioselective Fluorocyclization
Oscar Lozano, George Blessley, Teresa Martinez del Campo, Amber L. Thompson, Guy T. Giuffredi, Michela Bettati, Matthew Walker, Richard Borman, Véronique Gouverneur 
Angew. Chem. Int. Ed. 2011, 50, 8105-8109

118 Facile Synthesis of 4-Deoxy-4-fluoro-<alpha>-D-talopyranoside, 4-Deoxy-4-fluoro-<alpha>-D-idopyranoside and 2,4-Dideoxy-2,4-difluoro-alpha-D-talopyranoside
Guy T. Giuffredi, Laura E. Jennings, Bruno Bernet and Véronique Gouverneur 
J. Fluorine Chem. 2011, 132, 772-778 (Special Issue in honor of Alain Tressaud)

117 De Novo Synthesis of 4-Deoxy-4,4-Difluoro- and 2,4-Dideoxy-2,4,4-Trifluoro-Hexosides
Guy T. Giuffredi, Bruno Bernet and Véronique Gouverneur
Eur. J. Org. Chem. 2011, 3825-3836 (Special Issue Women in Chemistry)

116 AuI/AuIII Catalysis: An Alternative Approach for C-C Oxidative Coupling
Matthew N. Hopkinson, Antony D. Gee, Véronique. Gouverneur
Chem. Eur. J. 2011, 17, 8248-8262

115 Palladium-Catalyzed Allylic Fluorination
C. Hollingworth, A. Hazari, M. N. Hopkinson, M. Tredwell, E. Benedetto, M. Huiban, A. D. Gee, J. M. Brown and V. Gouverneur
Angew. Chem. Int. Ed. 2011, 50, 2613-2617. HOT Paper

114 Convergent 18F radiosynthesis: A new dimension for radiolabeling
Lei Li, M. N. Hopkinson, R. Leuma Yona, R. Bejot, A. D. Gee and V. Gouverneur
Chem. Sci. 2011, 2, 123-131

113 The Chemoselective One-Step Alkylation and Isolation of Thiophosphorylated Cdk2 Substrates in the Presence of Native Cysteine
S. E. Lee, L. M. Elphick, H. B. Kramer, A. M.E. Jones, E. S. Child, A.a A. Anderson, L. Bonnac, N. Suwaki, B. M. Kessler, V. Gouverneur, D. J. Mann
ChemBioChem. 2011, 12, 633-640

112 The Traceless Staudinger Ligation for Indirect 18F-Radiolabelling
L. Carroll, S. Boldon, R. Bejot, J. E. Moore, J. Declerck and V. Gouverneur
Org. Biomol. Chem. 2011, 9 (1), 136-140 HOT paper

111 Batch-mode microfluidic radiosynthesis of N-succinimidyl-4-[18F] fluorobenzoate for protein labeling
Romain Bejot, Akradij M. Elizarov, Carroll Ball, Jianzhong Zhang, Reza Miraghaie, Hartmuth C. Kolb, Véronique Gouverneur
J. Labelled Compounds and Radiopharmaceuticals 2011, 54, 117-122

110 Hypoxia Imaging Using PET and SPECT; The Effects of Anesthetic and Carrier Gas on [Cu-64]-ATSM, [(99)mTc-HL91 and [F-18]-FMISO Tumor Hypoxia Accumulation 
V. Keersemans, B. cornelissen, R. Hueting, M. Tredwell, J. Dilworth, V. Gouverneur, R. J. Muschel, S. C. Smart
PLOS One 2011, 6, Article Number: e25911 DOI: 10.1371/journal.pone.0025911