Véronique Gouverneur Research

Department of Chemistry University of Oxford

 

 

199 Synthesis of Fluorinated Alkyl Aryl Ethers by Palladium-Catalyzed C-O Cross-Coupling
R. Szpera, P. G. Isenegger, M. Ghosez, N. J. W. Straathof, R. Cookson, D. C. Blakemore, P. Richardson, V. Gouverneur
Org. Lett. 2020, DOI:10.1021/acs.orglett.0c02347

 

 

198 Hydrogen Bonding Phase-Transfer Catalysis with Ionic Reactants: Enantioselective Synthesis of γ-Fluoroamines
G. Roagna, D. Ascough, F. Ibba, A. C. Vicini, A. Fontana, K. Christensen, A. Peschiulli, D. Oehlrich, M. Misale, A. Trabanco, R. Paton, G. Pupo, V. Gouverneur
J. Am. Chem. Soc. 2020, DOI:10.1021/jacs.0c05131

 

197 Organophotoredox Hydrodefluorination of Trifluoromethylarenes with Translational Applicability to Drug Discovery
J. B. I. Sap, N. J. W. Straathof, T. Knauber, C. F. Meyer, M. Médebielle, L. Buglioni, C. Genicot, A. A. Trabanco, T. Noël, C. W. am Ende, V. Gouverneur
J. Am. Chem. Soc. 2020, 20, 9181–9187.DOI:10.1021/jacs.0c03881

 

196 [18F]AZD2461, an Insight on Difference in PARP Binding Profiles for DNA Damage Response PET Imaging
F. Guibbal, S. L. Hopkins, A. Pacelli, P. G. Isenegger, M. Mosley, J. B. Torres, G. M. Dias,    D. Mahaut, R. Hueting, V. Gouverneur, B. Cornelissen
Mol Imaging Biol. 2020, DOI:10.1007/s11307-020-01497-6

 

195 Hydrosulfonylation of Alkenes with Sulfonyl Chlorides under Visible Light Activation
S. M. Hell, C. F. Meyer, A. Misale, J. B. Sap, K. E. Christensen, M. C. Willis, A. A. Trabanco, V. Gouverneur
Angew. Chem. Int. Ed. 2020, 28, 11620–11626.DOI:10.1002/anie.202004070

 

194 Manual and automated Cu-mediated radiosynthesis of the PARP inhibitor
[18F]olaparib

F. Guibbal, P. G. Isenegger, T. C. Wilson, A. Pacelli, D. Mahaut, J. B. I. Sap, N. J. Taylor, S. Verhoog, S. Preshlock, R. Hueting, B. Cornelissen, V. Gouverneur

Nat Protoc. 2020, 15, 15251541.DOI:10.1038/s41596-020-0295-7

 

193 18F-Trifluoromethanesulfinate enables Direct C–H 18F-Trifluoromethylation of Native Aromatic Residues in Peptides
C. W. Kee, O. Tack, F. Guibbal, T. C. Wilson, P. G. Isenegger, M. Imiołek, S Verhoog, M. Tilby, G. Boscutti, S. Ashworth, J Chupin, R. Kashani, A. W. J. Poh, J. K. Sosabowski, S. Macholl, C. Plisson, B. Cornelissen, M. C. Willis, J. Passchier, B. G. Davis, V. Gouverneur
J. Am. Chem. Soc. 2020, 142, 1180-1185.DOI:10.1021/jacs.9b11709

 

192 Silyl Radical-Mediated Activation of Sulfamoyl Chlorides Enables Direct Access to Aliphatic Sulfonamides from Alkenes
S. M. Hell, C. F. Meyer, G. Laudadio, A. Misale, M. C. Willis, T. Noel, A. A. Trabanco, V. Gouverneur
J. Am. Chem. Soc. 2020, 142, 720-725.DOI:10.1021/jacs.9b13071

 

191 Hydrochlorofluoromethylation of Unactivated Alkenes with Chlorofluoroacetic Acid
C. F. Meyer, S. M. Hell, J. B. I. Sap, A. Misale, A. Peschiulli, D. Oehlrich, A. A. Trabanco, V. Gouverneur
Invited contribution to the special issue in honour of Professor Steve Davies.
Tetrahedron 2019, 75, 130679-130680.DOI:10.1016/j.tet.2019.130679

  

190 Imaging of translocator protein upregulation is selective for pro-inflammatory polarised astrocytes and microglia
M. Pannell, V. Economopoulos, T. C. Wilson, V.  Kersemans, P. G. Isenegger, J. R. Larkin, S. Smart, S. Gilchrist, V. Gouverneur, N. R. Sibson
GLIA 2019, 68, 280-297. DOI:10.1002/glia.23716

 

 189 In My Element: Fluorine
V. Gouverneur
In My Element series celebrates the personal accounts from Chemistry-
A European Journal Editorial Board members for the 2019 International Year
of the Periodic Table.
Chem. Eur. J.  2019, 25, 7958- 7959. DOI:10.1002/chem.201902265

  

 188 Hydrodifluoromethylation of Alkenes with Difluoroacetic Acid
C. F. Meyer, S. M. Hell, A. Misale, A. A. Trabanco, V. Gouverneur
Angew. Chem. Int. Ed. 2019, 58, 8828- 8833. DOI:10.1002/anie.201903801

    

187 The fluorination of C–H bonds: developments and perspectives
R. Szpera, D. F. J. Moseley, L. B. Smith, A. J. Sterling, V. Gouverneur
Angew. Chem. Int. Ed. 2019, 58, 14824-14848. DOI:10.1002/anie.201814457

 

186 Synthesis of 18F-Difluoromethylarenes Using Aryl Boronic Acids, Ethyl bromofluoroacetate and [18F]Fluoride
J. B. I. Sap, T. C. Wilson, C. W. Kee, N. J. W. Straathof, C. W. Amende, P. Mukherjee, L. Zhang, C. Genicot, V. Gouverneur
Chem. Sci. 2019, 10, 3237 - 3241. DOI: 10.1039/C8SC05096A

 

185 Hydrogen Bonding Phase-Transfer Catalysis with Potassium Fluoride: Enantioselective Synthesis of β-Fluoroamines
G. Pupo, A. C. Vicini, D. M. H. Ascough, F. Ibba, K. E. Christensen, A. L. Thompson, J. M. Brown, R. S. Paton, V. Gouverneur
J. Am. Chem. Soc. 2019, 141, 2878–2883. DOI: 10.1021/jacs.8b12568

 

184 Synthesis and Reactivity of a-Cumyl Bromodifluoromethanesulfenate: Application to the Radiosynthesis of [18F]ArylSCF3
J. Wu, Q. Zhao, T. C. Wilson, S. Verhoog, L. Lu, V. Gouverneur and Q. Shen
Angew. Chem. Int. Ed. 2019, 58, 1 – 6. DOI: 10.1002/anie.20181370

 

183 Data-mining the diaryl(thio)urea conformational landscape: Understanding the contrasting behavior of ureas and thioureas with quantum chemistry
G. Luchini, D. M. H. Ascough, J. V. Alegre-Requena, V. Gouverneur, R. S. Paton
Special Issue Paper: Computational Chemistry in Organic Synthesis. Guest Editors: Dean Tantillo and John Wood
Tetrahedron 2019, 75, 697-702. DOI: 10.1016/j.tet.2018.12.033

  

182 Enantioselective rhodium-catalysed insertion of trifluorodiazoethanes into tin hydrides S. Hyde, J. Veliks, D. M. H. Ascough, R. Szpera, R. S. Paton, V. Gouverneur
Special Issue in honour of Prof Leon Ghosez
Tetrahedron 2019, 75, 17-25. DOI: 10.1016/j.tet.2018.11.022

 

181 PET Imaging of PARP Expression Using 18F-Olaparib
T. C. Wilson, M. A. Xavier, J. Knight, S. Verhoog, J. B. Torres, M. Mosley, S. L. Hopkins, S. Wallington, P. D. Allen, V. Kersemans, R. Hueting, S. Smart, V. Gouverneur, B. Cornelissen
J. Nucl. Med. 2019, 60, 504-510. DOI: 10.2967/jnumed.118.213223

 

180 Boron reagents for divergent radiochemistry
T. C. Wilson, T. Cailly, V. Gouverneur
Chem Soc Rev2018, 47, 6990-7005. DOI: 10.1039/c8cs00499d

 

 

179 Asymmetric nucleophilic fluorination under hydrogen bonding phase-transfer catalysis
G. Pupo, F. Ibba, D. M. H. Ascough, A. C. Vicini, P. Ricci, K. E. Christensen, L. Pfeifer, J. R. Morphy, J. M. Brown, R. S. Paton, V. Gouverneur
Science 2018, 360, 638-642. DOI: 10.1126/science.aar7941

 

 178 Highly Diastereoselective Synthesis of Trifluoromethyl Indolines by Interceptive Benzylic Decarboxylative Cycloaddition of Nonvinyl, Trifluoromethyl Benzoxazinanones with Sulfur Ylides under Palladium Catalysis
N. Punna, P. Das, V. Gouverneur, N. Shibata

Org. Lett. 2018, 20, 1526-1529. DOI: 10.1021/acs.orglett.8b00237

 

177 Controlled Single and Double Iodofluorination of Alkynes with DIH- and HF-Based Reagents
L. Pfeifer, V. Gouverneur

Org. Lett. 2018, 20, 1576-1579. DOI: 10.1021/acs.orglett.8b00321

 

176 Selective Radical Trifluoromethylation of Native Residues in Proteins
M. Imiołek, G. Karunanithy, W-L. Ng, A. J. Baldwin, V. Gouverneur, B. G. Davis
J. Am. Chem. Soc. 2018, 7, 1568-1571. DOI: 10.1021/jacs.7b10230

 

 

175 18F-Trifluoromethylation of Unmodified Peptides with 5-18F-(Trifluoromethyl)dibenzothiophenium Trifluoromethanesulfonate
S. Verhoog, C. W. Kee, Y. Wang, T. Khotavivattana, T. C. Wilson, V. Kersemans, S. Smart, M. Tredwell, B. G. Davis, V. Gouverneur
J. Am. Chem. Soc. 2018, 7, 1572-1575. DOI: 10.1021/jacs.7b10227

 

174 Synthesis, characterization, thermal and surface properties of co- and terpolymers based on fluorinated a-methylstyrenes and styrene
J. Walkowiak-Kulikowska, A. Szwajca, V. Gouverneur, B. Ameduri 
Polym. Chem-Uk 2017, 8, 6558-6569. DOI: 10.1039/C7PY01529A

 

173 De-Risking the Cu-Mediated 18F-Fluorination of Heterocyclic PET Radioligands
N. J. Taylor, E. Emer, S. Preshlock, M. Schedler, M. Tredwell, S. Verhoog, J. Mercier, C. Genicot, V. Gouverneur
J. Am. Chem. Soc. 2017, 139, 8267-8276. DOI: 10.1021/jacs.7b03131

 

172 Synthesis and Reactivity of 18F-Labeled α,α-Difluoro-α-Aryloxyacetic Acids
T. Khotavivattana, S. Calderwood, S. Verhoog, L. Pfeifer, S. Preshlock, N. Vasdev, T. L. Collier, V. Gouverneur
Org. Lett. 2017, 19, 568-571. DOI: 10.1021/acs.orglett.6b03730

 

171 The Dual Role of Thiourea in the Thiotrifluoromethylation of Alkenes 
P. Ricci, T. Khotavivattana, L. Pfeifer, M. Médebielle, J. R. Morphy, V. Gouverneur 
Chem. Sci. 2017, 8, 1195-1199. DOI: 10.1039/C6SC02790C

 
 

170 Bridging the gaps in 18F PET tracer development 
M. G. Campbell, J. Mercier, C. Genicot, V. Gouverneur, J. M. Hooker, T. Ritter 
Nat. Chem.
2017, 9, 1-3. DOI: 10.1038/nchem.2693 

 

 

169 Twisting the Ethano-Tröger’s Base: The Bisamide 
R. Pereira, L. Pfeifer, J. Fournier, V. Gouverneur V, J. Cvengroš
Org. Biomol. Chem. 2017, 15, 628-633. DOI: 10.1039/C6OB02359B