Véronique Gouverneur Research

Department of Chemistry University of Oxford



199 Synthesis of Fluorinated Alkyl Aryl Ethers by Palladium-Catalyzed C-O Cross-Coupling
R. Szpera, P. G. Isenegger, M. Ghosez, N. J. W. Straathof, R. Cookson, D. C. Blakemore, P. Richardson, V. Gouverneur
Org. Lett. 2020, DOI:10.1021/acs.orglett.0c02347



198 Hydrogen Bonding Phase-Transfer Catalysis with Ionic Reactants: Enantioselective Synthesis of γ-Fluoroamines
G. Roagna, D. Ascough, F. Ibba, A. C. Vicini, A. Fontana, K. Christensen, A. Peschiulli, D. Oehlrich, M. Misale, A. Trabanco, R. Paton, G. Pupo, V. Gouverneur
J. Am. Chem. Soc. 2020, DOI:10.1021/jacs.0c05131


197 Organophotoredox Hydrodefluorination of Trifluoromethylarenes with Translational Applicability to Drug Discovery
J. B. I. Sap, N. J. W. Straathof, T. Knauber, C. F. Meyer, M. Médebielle, L. Buglioni, C. Genicot, A. A. Trabanco, T. Noël, C. W. am Ende, V. Gouverneur
J. Am. Chem. Soc. 2020, 20, 9181–9187.DOI:10.1021/jacs.0c03881


196 [18F]AZD2461, an Insight on Difference in PARP Binding Profiles for DNA Damage Response PET Imaging
F. Guibbal, S. L. Hopkins, A. Pacelli, P. G. Isenegger, M. Mosley, J. B. Torres, G. M. Dias,    D. Mahaut, R. Hueting, V. Gouverneur, B. Cornelissen
Mol Imaging Biol. 2020, DOI:10.1007/s11307-020-01497-6


195 Hydrosulfonylation of Alkenes with Sulfonyl Chlorides under Visible Light Activation
S. M. Hell, C. F. Meyer, A. Misale, J. B. Sap, K. E. Christensen, M. C. Willis, A. A. Trabanco, V. Gouverneur
Angew. Chem. Int. Ed. 2020, 28, 11620–11626.DOI:10.1002/anie.202004070


194 Manual and automated Cu-mediated radiosynthesis of the PARP inhibitor

F. Guibbal, P. G. Isenegger, T. C. Wilson, A. Pacelli, D. Mahaut, J. B. I. Sap, N. J. Taylor, S. Verhoog, S. Preshlock, R. Hueting, B. Cornelissen, V. Gouverneur

Nat Protoc. 2020, 15, 15251541.DOI:10.1038/s41596-020-0295-7


193 18F-Trifluoromethanesulfinate enables Direct C–H 18F-Trifluoromethylation of Native Aromatic Residues in Peptides
C. W. Kee, O. Tack, F. Guibbal, T. C. Wilson, P. G. Isenegger, M. Imiołek, S Verhoog, M. Tilby, G. Boscutti, S. Ashworth, J Chupin, R. Kashani, A. W. J. Poh, J. K. Sosabowski, S. Macholl, C. Plisson, B. Cornelissen, M. C. Willis, J. Passchier, B. G. Davis, V. Gouverneur
J. Am. Chem. Soc. 2020, 142, 1180-1185.DOI:10.1021/jacs.9b11709


192 Silyl Radical-Mediated Activation of Sulfamoyl Chlorides Enables Direct Access to Aliphatic Sulfonamides from Alkenes
S. M. Hell, C. F. Meyer, G. Laudadio, A. Misale, M. C. Willis, T. Noel, A. A. Trabanco, V. Gouverneur
J. Am. Chem. Soc. 2020, 142, 720-725.DOI:10.1021/jacs.9b13071


191 Hydrochlorofluoromethylation of Unactivated Alkenes with Chlorofluoroacetic Acid
C. F. Meyer, S. M. Hell, J. B. I. Sap, A. Misale, A. Peschiulli, D. Oehlrich, A. A. Trabanco, V. Gouverneur
Invited contribution to the special issue in honour of Professor Steve Davies.
Tetrahedron 2019, 75, 130679-130680.DOI:10.1016/j.tet.2019.130679


190 Imaging of translocator protein upregulation is selective for pro-inflammatory polarised astrocytes and microglia
M. Pannell, V. Economopoulos, T. C. Wilson, V.  Kersemans, P. G. Isenegger, J. R. Larkin, S. Smart, S. Gilchrist, V. Gouverneur, N. R. Sibson
GLIA 2019, 68, 280-297. DOI:10.1002/glia.23716


 189 In My Element: Fluorine
V. Gouverneur
In My Element series celebrates the personal accounts from Chemistry-
A European Journal Editorial Board members for the 2019 International Year
of the Periodic Table.
Chem. Eur. J.  2019, 25, 7958- 7959. DOI:10.1002/chem.201902265


 188 Hydrodifluoromethylation of Alkenes with Difluoroacetic Acid
C. F. Meyer, S. M. Hell, A. Misale, A. A. Trabanco, V. Gouverneur
Angew. Chem. Int. Ed. 2019, 58, 8828- 8833. DOI:10.1002/anie.201903801


187 The fluorination of C–H bonds: developments and perspectives
R. Szpera, D. F. J. Moseley, L. B. Smith, A. J. Sterling, V. Gouverneur
Angew. Chem. Int. Ed. 2019, 58, 14824-14848. DOI:10.1002/anie.201814457


186 Synthesis of 18F-Difluoromethylarenes Using Aryl Boronic Acids, Ethyl bromofluoroacetate and [18F]Fluoride
J. B. I. Sap, T. C. Wilson, C. W. Kee, N. J. W. Straathof, C. W. Amende, P. Mukherjee, L. Zhang, C. Genicot, V. Gouverneur
Chem. Sci. 2019, 10, 3237 - 3241. DOI: 10.1039/C8SC05096A


185 Hydrogen Bonding Phase-Transfer Catalysis with Potassium Fluoride: Enantioselective Synthesis of β-Fluoroamines
G. Pupo, A. C. Vicini, D. M. H. Ascough, F. Ibba, K. E. Christensen, A. L. Thompson, J. M. Brown, R. S. Paton, V. Gouverneur
J. Am. Chem. Soc. 2019, 141, 2878–2883. DOI: 10.1021/jacs.8b12568


184 Synthesis and Reactivity of a-Cumyl Bromodifluoromethanesulfenate: Application to the Radiosynthesis of [18F]ArylSCF3
J. Wu, Q. Zhao, T. C. Wilson, S. Verhoog, L. Lu, V. Gouverneur and Q. Shen
Angew. Chem. Int. Ed. 2019, 58, 1 – 6. DOI: 10.1002/anie.20181370


183 Data-mining the diaryl(thio)urea conformational landscape: Understanding the contrasting behavior of ureas and thioureas with quantum chemistry
G. Luchini, D. M. H. Ascough, J. V. Alegre-Requena, V. Gouverneur, R. S. Paton
Special Issue Paper: Computational Chemistry in Organic Synthesis. Guest Editors: Dean Tantillo and John Wood
Tetrahedron 2019, 75, 697-702. DOI: 10.1016/j.tet.2018.12.033


182 Enantioselective rhodium-catalysed insertion of trifluorodiazoethanes into tin hydrides S. Hyde, J. Veliks, D. M. H. Ascough, R. Szpera, R. S. Paton, V. Gouverneur
Special Issue in honour of Prof Leon Ghosez
Tetrahedron 2019, 75, 17-25. DOI: 10.1016/j.tet.2018.11.022


181 PET Imaging of PARP Expression Using 18F-Olaparib
T. C. Wilson, M. A. Xavier, J. Knight, S. Verhoog, J. B. Torres, M. Mosley, S. L. Hopkins, S. Wallington, P. D. Allen, V. Kersemans, R. Hueting, S. Smart, V. Gouverneur, B. Cornelissen
J. Nucl. Med. 2019, 60, 504-510. DOI: 10.2967/jnumed.118.213223


180 Boron reagents for divergent radiochemistry
T. C. Wilson, T. Cailly, V. Gouverneur
Chem Soc Rev2018, 47, 6990-7005. DOI: 10.1039/c8cs00499d



179 Asymmetric nucleophilic fluorination under hydrogen bonding phase-transfer catalysis
G. Pupo, F. Ibba, D. M. H. Ascough, A. C. Vicini, P. Ricci, K. E. Christensen, L. Pfeifer, J. R. Morphy, J. M. Brown, R. S. Paton, V. Gouverneur
Science 2018, 360, 638-642. DOI: 10.1126/science.aar7941


 178 Highly Diastereoselective Synthesis of Trifluoromethyl Indolines by Interceptive Benzylic Decarboxylative Cycloaddition of Nonvinyl, Trifluoromethyl Benzoxazinanones with Sulfur Ylides under Palladium Catalysis
N. Punna, P. Das, V. Gouverneur, N. Shibata

Org. Lett. 2018, 20, 1526-1529. DOI: 10.1021/acs.orglett.8b00237


177 Controlled Single and Double Iodofluorination of Alkynes with DIH- and HF-Based Reagents
L. Pfeifer, V. Gouverneur

Org. Lett. 2018, 20, 1576-1579. DOI: 10.1021/acs.orglett.8b00321


176 Selective Radical Trifluoromethylation of Native Residues in Proteins
M. Imiołek, G. Karunanithy, W-L. Ng, A. J. Baldwin, V. Gouverneur, B. G. Davis
J. Am. Chem. Soc. 2018, 7, 1568-1571. DOI: 10.1021/jacs.7b10230



175 18F-Trifluoromethylation of Unmodified Peptides with 5-18F-(Trifluoromethyl)dibenzothiophenium Trifluoromethanesulfonate
S. Verhoog, C. W. Kee, Y. Wang, T. Khotavivattana, T. C. Wilson, V. Kersemans, S. Smart, M. Tredwell, B. G. Davis, V. Gouverneur
J. Am. Chem. Soc. 2018, 7, 1572-1575. DOI: 10.1021/jacs.7b10227


174 Synthesis, characterization, thermal and surface properties of co- and terpolymers based on fluorinated a-methylstyrenes and styrene
J. Walkowiak-Kulikowska, A. Szwajca, V. Gouverneur, B. Ameduri 
Polym. Chem-Uk 2017, 8, 6558-6569. DOI: 10.1039/C7PY01529A


173 De-Risking the Cu-Mediated 18F-Fluorination of Heterocyclic PET Radioligands
N. J. Taylor, E. Emer, S. Preshlock, M. Schedler, M. Tredwell, S. Verhoog, J. Mercier, C. Genicot, V. Gouverneur
J. Am. Chem. Soc. 2017, 139, 8267-8276. DOI: 10.1021/jacs.7b03131


172 Synthesis and Reactivity of 18F-Labeled α,α-Difluoro-α-Aryloxyacetic Acids
T. Khotavivattana, S. Calderwood, S. Verhoog, L. Pfeifer, S. Preshlock, N. Vasdev, T. L. Collier, V. Gouverneur
Org. Lett. 2017, 19, 568-571. DOI: 10.1021/acs.orglett.6b03730


171 The Dual Role of Thiourea in the Thiotrifluoromethylation of Alkenes 
P. Ricci, T. Khotavivattana, L. Pfeifer, M. Médebielle, J. R. Morphy, V. Gouverneur 
Chem. Sci. 2017, 8, 1195-1199. DOI: 10.1039/C6SC02790C


170 Bridging the gaps in 18F PET tracer development 
M. G. Campbell, J. Mercier, C. Genicot, V. Gouverneur, J. M. Hooker, T. Ritter 
Nat. Chem.
2017, 9, 1-3. DOI: 10.1038/nchem.2693 



169 Twisting the Ethano-Tröger’s Base: The Bisamide 
R. Pereira, L. Pfeifer, J. Fournier, V. Gouverneur V, J. Cvengroš
Org. Biomol. Chem. 2017, 15, 628-633. DOI: 10.1039/C6OB02359B