Véronique Gouverneur Research

Department of Chemistry University of Oxford


193 18F-Trifluoromethanesulfinate enables Direct C–H 18F-Trifluoromethylation of Native Aromatic Residues in Peptides
Kee C, Tack O, Guibbal F, Wilson T, Isenegger P, Imiołek M, Verhoog S, Tilby M, Boscutti G, Ashworth S, Chupin J, Kashani R, Poh A, Sosabowski J, Macholl S, Plisson C, Cornelissen B, Willis M, Passchier J, Davis B, Gouverneur V
J. Am. Chem. Soc. 2020, DOI:10.1021/jacs.9b11709


192 Silyl Radical-Mediated Activation of Sulfamoyl Chlorides Enables Direct Access to Aliphatic Sulfonamides from Alkenes
Hell S, Meyer C, Laudadio G, Misale A, Willis M, Noel T, Trabanco A, Gouverneur V
J. Am. Chem. Soc. 2020142, 720-725.DOI:10.1021/jacs.9b13071


191 Hydrochlorofluoromethylation of Unactivated Alkenes with Chlorofluoroacetic Acid
Meyer C, Hell S, Sap J, Misale A, Peschiulli A, Oehlrich D, Trabanco A, Gouverneur V
Invited contribution to the special issue in honour of Professor Steve Davies.
Tetrahedron 2019, DOI:10.1016/j.tet.2019.130679


190 Imaging of translocator protein upregulation is selective for pro-inflammatory polarised astrocytes and microglia
Pannell M, Economopoulos V, Wilson T, Kersemans V, Isenegger P, Larkin J, Smart S, Gilchrist S, Gouverneur V, Sibson N
GLIA 2019, 68, 280-297. DOI:10.1002/glia.23716


 189 In My Element: Fluorine
Gouverneur V
In My Element series celebrates the personal accounts from Chemistry-
A European Journal Editorial Board members for the 2019 International Year
of the Periodic Table.
Chem. Eur. J.  2019, 25, 7958- 7959. DOI:10.1002/chem.201902265


 188 Hydrodifluoromethylation of Alkenes with Difluoroacetic Acid
Meyer C, Hell S, Misale A, Trabanco A, Gouverneur V
Angew. Chem. Int. Ed. 2019, 58, 8828- 8833. DOI:10.1002/anie.201903801


187 The fluorination of C–H bonds: developments and perspectives
Szpera R, Moseley D, Smith L, Sterling A, Gouverneur V
Angew. Chem. Int. Ed. 2019, 58, 14824-14848. DOI:10.1002/anie.201814457


186 Synthesis of 18F-Difluoromethylarenes Using Aryl Boronic Acids, Ethyl bromofluoroacetate and [18F]Fluoride
Sap J, Wilson T, Kee C, Straathof N, Amende C, Mukherjee P, Zhang L, Genicot C, Gouverneur V
Chem. Sci. 2019, 10, 3237 - 3241. DOI: 10.1039/C8SC05096A


185 Hydrogen Bonding Phase-Transfer Catalysis with Potassium Fluoride: Enantioselective Synthesis of β-Fluoroamines
Pupo G, Vicini A, Ascough D, Ibba F, Christensen K, Thompson A , Brown J , Paton R, Gouverneur V
J. Am. Chem. Soc. 2019, 141, 2878–2883. DOI: 10.1021/jacs.8b12568


184 Synthesis and Reactivity of a-Cumyl Bromodifluoromethanesulfenate: Application to the Radiosynthesis of [18F]ArylSCF3
Wu J, Zhao Q, Wilson T, Verhoog S, Lu L, Gouverneur V and Shen Q
Angew. Chem. Int. Ed. 2019, 58, 1 – 6. DOI: 10.1002/anie.20181370


183 Data-mining the diaryl(thio)urea conformational landscape: Understanding the contrasting behavior of ureas and thioureas with quantum chemistry
Luchini G, Ascough D, Alegre-Requena J, Gouverneur V, Paton R
Special Issue Paper: Computational Chemistry in Organic Synthesis. Guest Editors: Dean Tantillo and John Wood
Tetrahedron 2019, 75, 697-702. DOI: 10.1016/j.tet.2018.12.033


182 Enantioselective rhodium-catalysed insertion of trifluorodiazoethanes into tin hydrides Hyde S, Veliks J, Ascough D, Szpera R, Paton R, Gouverneur V
Special Issue in honour of Prof Leon Ghosez
Tetrahedron 2019, 75, 17-25. DOI: 10.1016/j.tet.2018.11.022


181 PET Imaging of PARP Expression Using 18F-Olaparib
Wilson T, Xavier M, Knight J, Verhoog S, Torres J, Mosley M, Hopkins S, Wallington S, Allen P, Kersemans V, Hueting R, Smart S, Gouverneur V, Cornelissen B
J. Nucl. Med. 2019, 60, 504-510. DOI: 10.2967/jnumed.118.213223


180 Boron reagents for divergent radiochemistry
Wilson T, Cailly T, Gouverneur V
Chem Soc Rev2018, 47, 6990-7005. DOI: 10.1039/c8cs00499d



179 Asymmetric nucleophilic fluorination under hydrogen bonding phase-transfer catalysis
Pupo G, Ibba F, Ascough D, Vicini A, Ricci P, Christensen K, Pfeifer L, Morphy J, Brown J, Paton R, Gouverneur V
Science 2018, 360, 638-642. DOI: 10.1126/science.aar7941


 178 Highly Diastereoselective Synthesis of Trifluoromethyl Indolines by Interceptive Benzylic Decarboxylative Cycloaddition of Nonvinyl, Trifluoromethyl Benzoxazinanones with Sulfur Ylides under Palladium Catalysis
Punna N, Das P, Gouverneur V, Shibata N

Org. Lett. 2018, 20, 1526-1529. DOI: 10.1021/acs.orglett.8b00237


177 Controlled Single and Double Iodofluorination of Alkynes with DIH- and HF-Based Reagents
Pfeifer L, Gouverneur V

Org. Lett. 2018, 20, 1576-1579. DOI: 10.1021/acs.orglett.8b00321


176 Selective Radical Trifluoromethylation of Native Residues in Proteins
Imiołek M, Karunanithy G, Ng W, Baldwin A, Gouverneur V, Davis B
J. Am. Chem. Soc. 2018, 7, 1568-1571. DOI: 10.1021/jacs.7b10230



175 18F-Trifluoromethylation of Unmodified Peptides with 5-18F-(Trifluoromethyl)dibenzothiophenium Trifluoromethanesulfonate
Verhoog S, Kee C, Wang Y, Khotavivattana T, Wilson T, Kersemans V, Smart S, Tredwell M, Davis B, Gouverneur V
J. Am. Chem. Soc. 2018, 7, 1572-1575. DOI: 10.1021/jacs.7b10227


174 Synthesis, characterization, thermal and surface properties of co- and terpolymers based on fluorinated a-methylstyrenes and styrene
Walkowiak-Kulikowska J, Szwajca A, Gouverneur V, Ameduri B 
Polym. Chem-Uk 2017, 8, 6558-6569. DOI: 10.1039/C7PY01529A


173 De-Risking the Cu-Mediated 18F-Fluorination of Heterocyclic PET Radioligands
Taylor N, Emer E, Preshlock S, Schedler M, Tredwell M, Verhoog S, Mercier J, Genicot C, Gouverneur V
J. Am. Chem. Soc. 2017, 139, 8267-8276. DOI: 10.1021/jacs.7b03131


172 Synthesis and Reactivity of 18F-Labeled α,α-Difluoro-α-Aryloxyacetic Acids
Khotavivattana T, Calderwood S, Verhoog S, Pfeifer L, Preshlock S, Vasdev N, Collier T, Gouverneur V
Org. Lett. 2017, 19, 568-571. DOI: 10.1021/acs.orglett.6b03730


171 The Dual Role of Thiourea in the Thiotrifluoromethylation of Alkenes 
Ricci P, Khotavivattana T, Pfeifer L, Médebielle M, Morphy J, Gouverneur V 
Chem. Sci. 2017, 8, 1195-1199. DOI: 10.1039/C6SC02790C


170 Bridging the gaps in 18F PET tracer development 
Campbell M, Mercier J, Genicot C, Gouverneur V, Hooker J, Ritter T 
Nat. Chem.
2017, 9, 1-3. DOI: 10.1038/nchem.2697 



169 Twisting the Ethano-Tröger’s Base: The Bisamide 
Cvengros J, Pereira R, Pfeifer L, Fournier J, Gouverneur V
Org. Biomol. Chem. 2017, 15, 628-633. DOI: 10.1039/C6OB02359B